Micky van de Ven Double Ends Everton's Unbeaten Streak at Brand New Stadium
Micky van de Ven became the first backline player to net two goals in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
Match summary
Micky Van de Ven heads home twice in first half
The home side's Jake O'Brien has goal disallowed after video check
Pape Matar Sarr nets final goal in 89th minute
This loss is the Merseyside club's first at their new ground
The Tottenham defender found the net on two occasions as Spurs extended their unbeaten run in away games in the top division and delivered the Toffees their first defeat at Hill Dickinson Stadium.
Everton were unbeaten in their last five matches at their recently opened stadium at the dockside location, having departed their historic home behind after more than a century at the end of last season.
But Spurs captain Van de Ven struck twice from set-pieces in the opening 45 minutes to put their impressive record at jeopardy, and they were unable to mount a comeback before Pape Matar Sarr - assisted by former Toffees attacker the Brazilian - nodded in a third to seal the victory.
Jake O'Brien thought he had levelled the scores a short while after Van de Ven's first goal, glancing a powerful header past the Spurs keeper from an Everton corner.
Beto, in the meantime, missed a number of chances, while Vicario made a succession of fine stops to ensure the London club went five matches on the road without defeat in the Premier League.
But the video assistant referee stepped in, instructing the match official to check the goal on the screen and the official decided that the winger and Iliman Ndiaye were in an illegal position and had impeded with the Spurs keeper.
The win moves Thomas Frank's team up to third in the Premier League, a handful of points off local foes and table-toppers the Gunners.
The Merseyside club remain 14th and sit half a dozen points clear of the relegation zone.
Spurs breakdown: Van de Ven fulfils role at each end of pitch
After a uninspiring midweek display in the European competition against Monaco, where they managed a mere two shots on goal, Frank chose Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was failed to make much of an impact before being substituted for the substitute after an hour on the field, but it turns out he proved unnecessary in the final outcome.
Defender Van de Ven converted into an offensive threat to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball back across the six-yard box for an unmarked the defender to head home.
And the captain - stepping up as skipper in Cristian Romero's absence - notched his second in added time as he rose above the England keeper to nod in.
The Dutchman was equally impressive in defensive duties, combining effectively with his defensive colleague as the pair dealt superbly with the numerous deliveries sent their way by Everton.
Toffees breakdown: Everton lacking finishing touch
Everton's new home had been a fortress, but it appears the freshness may have faded somewhat and fans headed to the exits after the midfielder's final goal for Tottenham.
The end in the team's unbeaten home run won't be a massive worry for the manager, but their attacking woes will be.
The forward and the other striker - the Toffees' pair of established strikers - had netted only one league goal combined before the weekend's match.
And they were failed to add to that poor tally on a damp and dreary evening on in Liverpool.
The striker's performance was epitomized when he opted to bicycle-kick a clear chance from close range, even with having space and time to readjust for a more conventional shot that would have tested the keeper.
The substitute, too, was unable to make an impact after coming on for the starter in the 65th minute.
It was not for a lack of opportunity. Most of the home side's offensive moves came through Grealish and the forward, who tirelessly whipped dangerous balls into the Spurs penalty area.
What next for these two sides?
The Toffees: The team head to the Stadium of Light in the Premier League on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs go to Newcastle's ground on Wednesday, 29 October for their next round League Cup match against the Magpies.